Predictive factors for transient IgA deficiency

Authors

Keywords:

Transient IgA deficiency, Secondary immunodeficiency, Predisposing factors, Dysbiosis.

Abstract

Permanent or transient immunoglobulin A deficiency is the most common primary immunodeficiency. Knowledge of factors associated with transient deficit would allow its prevention and better diagnostic and therapeutic management. A case-control study was conducted to identify predisposing factors for the development of transient IgA deficiency in Granma in 78 patients (26 cases, 52 controls) seen in the Immunology clinic between 2012 and 2024. Clinical and epidemiological variables were evaluated, using Odds Ratio (OR-CI 95%) and multivariate analysis with a logistic regression model. The univariate analysis showed the following predisposing factors: cesarean birth, absence of breastfeeding, medication consumption, protein loss, presence of celiac disease, malnutrition and presence of dysbiosis; the latter was the most important variable with independent influence in the multivariate analysis (OR 9.55-95% CI, p=0.032). Dysbiosis, cesarean birth, and lack of breastfeeding were predisposing factors for transient IgA deficiency.

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Published

2025-02-26

How to Cite

1.
Marrón Gonzalez R, Pérez Acevedo LC, González Costa M, Reyes Fajardo M, Addine Ramírez B de la C. Predictive factors for transient IgA deficiency. RM [Internet]. 2025 Feb. 26 [cited 2025 Jul. 14];29:e2974. Available from: https://revmultimed.sld.cu/index.php/mtm/article/view/2974

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Section

ARTÍCULOS ORIGINALES