Toxic epidermal necrolysis due to penicillin. A case presentation.

Authors

  • Juan Carlos Fonseca Muñoz Hospital Provincial “Carlos Manuel de Céspedes”. Bayamo
  • Alexis Álvarez Aliaga Hospital Provincial “Carlos Manuel de Céspedes”. Bayamo.
  • Adonis Frómeta Guerra Hospital Provincial “Carlos Manuel de Céspedes”. Bayamo.
  • Tamara Alicia Fonseca Muñoz Filial de Ciencias Médicas. Bayamo.

Keywords:

EPIDERMAL NECROLYSIS, Toxic /diagnosis, EPIDERMAL NECROLYSIS /complications, EPIDERMAL NECROLYSIS /therapy

Abstract

The toxic epidermal necrolysis is a skin disorder that can risk life and it is characterized by the formation of vesicles and skin exfoliation. It may be provoked by drugs reaction, mainly antibiotics or anti-convulsing. Approximately in a third of cases of Toxic Epidermal Necrolysis it is not possible to identify the cause. The mortality is high, about 35-40%. It is not known the effective treatment for it yet, although there have been proved different therapies with uneven results. We present a case of a healthy 21- year -old man with this disorder provoked by penicillin, who required multiple therapy, including intravenous immunoglobuline with satisfactory evolution.    

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References

1. Roujeau JC, Nelly JP, Naldi L. Medication use and the risk of Stevens-Johnson Syndrome or Toxix Epidermal Necrolysis. N Engl J Med. 1995; 333: 1600-7.

2. Schwartz RA. Toxic Epidermal Necrolysis. Cutis. 1997; 59(3):123-8.

3. Andresen MH, Boguero Y, Molgo M. Necrólisis epidérmica tóxica. Terapia en UCI con inmunoglobulinas intravenosas en un caso. Rev Med Chile. 2000; 128(12): 1343-8.

4. Magina S, Lisboa C, Concalves E, Conceicao F, Leal V, Mesquita J. A case of toxic epidermal necrólisis treated with intravenous inmunoglobulin. Br J Dermatol. 2000; 142: 177-99.

5. García-Doval I, LeCleach L, Bocquet H, Otero X, Roujeau J. Toxic epidermal necrólisis and Steven-Johnson syndrome, Arch Dermatol. 2000; 136: 323-7.

6. De Juan Martín F, Bouthelier Moreno M, Marín Bravo MC, Melendo Jimeno J. Necrólisis epidérmica tóxica tratada con inmunoglobulina intravenosa. An Esp Pediatr. 2002; 56: 370.

7. Ruiz M. Acute disseminated epidermal necrólisis, Study of 60 cases. J Am Acad Dermatol. 1985; 13: 623-35.

8. Prendiville J. Stevens-Johnson syndrome and toxic epidermal necrólisis. Adv dermatol. 2002; 18: 151-73.

9. Lipper G, Arndt K, Dover J. Recent therapeutic advances in dermatology. Jama. 2000; 283: 175-7.

10. Leyva L, Torres MJ, Posadas S, Blanca M, Besso G, O’Valle F. Anticonvulsant-induced toxic epidermal necrólisis: Monitoring the inminologic response. J Allergy Clin Inmunol. 2000; 105:157-65.

Published

2011-01-05

How to Cite

1.
Fonseca Muñoz JC, Álvarez Aliaga A, Frómeta Guerra A, Fonseca Muñoz TA. Toxic epidermal necrolysis due to penicillin. A case presentation. RM [Internet]. 2011 Jan. 5 [cited 2025 Jun. 5];15(1). Available from: https://revmultimed.sld.cu/index.php/mtm/article/view/1527

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Section

CASOS CLÍNICOS